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KMID : 0882420140870010105
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Korean Journal of Medicine
2014 Volume.87 No. 1 p.105 ~ p.109
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Antibiotic-Induced Acquired Factor V Inhibitor
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Lim Doo-Ho
Kim Tae-Oh
Jeong Yu-Mun
Kim Won-Jang
Park Seung-Jung
Lee Je-Hwan
Jang Seong-Soo
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Abstract
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Acquired factor V inhibitor is a rare condition with a variety of clinical manifestations that range from no bleeding symptoms to life-threatening hemorrhage or thromboembolic events. Treatment is determined by the clinical course and focuses on controlling the hemorrhagic event and decreasing the antibody titer if bleeding symptoms are present. We report herein a case involving a 70-year-old man who developed acquired factor V inhibitor after antibiotic administration (11-day course of ceftriaxone and successive 5-day course of piperacillin-tazobactam) for pneumonia. His condition was characterized by elevated prothrombin and activated partial thromboplastin times without bleeding events. Coagulation factor assays revealed undetectable factor V activity and a factor V inhibitor level of 3.29 Bethesda units. After cessation of the antibiotics, both the prothrombin and activated partial thromboplastin times gradually normalized.
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KEYWORD
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Factor V deficiency, Inhibitor, Blood coagulation factor, Factor V, Antibiotics
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